102-52-3, name is 1,1,3,3-Tetramethoxypropane, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: ethers-buliding-blocks
Stage 5- Preparation of 3-(phenylamino)allylidene)aniline hydrochloride (Bioorg. Med. Chem. 2006, 4, 92-97). Compound having formula (VI) where n=1. 24.7 g of aniline in solution in 300 mL of 0.75 N HCl is added drop by drop to 21.8 g of 1,1,3,3-tetramethoxypropane in solution in 300 mL of 0.75 N HCl. The appearance of an intense orange colour and the precipitation of an orange crystalline solid are observed. The medium is then left under stirring for 3 hours at 50 C. The cooled medium is filtered, vacuum-dried to obtain 15.2 g of orange solid (Yd=44.2%). C15H14N2, HCl-(Mass ESI+400 C. MH+=223.1).
The synthetic route of 102-52-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); PIERRE FABRE MEDICAMENT; Guminski, Yves; Imbert, Thierry; Pesnel, Sabrina; Pillon, Arnaud; Le Pape, Alain; Lerondel, Stephanie; US2013/183247; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem