Electric Literature of 39021-83-5, The chemical industry reduces the impact on the environment during synthesis 39021-83-5, name is 1,4-Dimethoxy-2,3-dimethylbenzene, I believe this compound will play a more active role in future production and life.
General procedure: A 100-mL round-bottomed flask was charged with 6 g of silica gel and set up tostir vigorously. Then, a solution of 2.75 g of cerium ammonium nitrate (CAN) (5.0mmol) in water (2.5 mL) was added dropwise. The stirring continued until a freeflowingyellow solid was obtained. DCM (25 mL) was then added to the flask. Thecorresponding substrates where dissolved in 2 mL of DCM and added to the stirredreaction mixture. The reaction was monitored by TLC and after complete consumptionof the starting materials the mixture was filtered through a sintered-glass funnel. Thesolid was washed with about 75 mL of DCM. After solvent removal the quinones wereobtained with high purity. 2,3-Dimethyl-1,4-benzoquinone (46): 1,4-dimethoxy-2,3-dimethylbenzene(43)6 (1 mmol, 166 mg) was used. 46 was obtained without the need of purification (85mg, 63% yield) as an orange powder; m.p. (C) = 54.9-56.4 (Petrol/CH2Cl2); HRMS(EI+): 136.0569 [M]+. Cald. for [C8H8O2]: 136.0524; 1H NMR (400 MHz, CDCl3) delta:6.70 (s, 2H), 2.01 (s, 6H); 13C NMR (100 MHz, CDCl3) delta: 187.4, 141.0, 136.2, 12.2.Data are consistent with those reported in the literature.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,4-Dimethoxy-2,3-dimethylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Jardim, Guilherme A.M.; Silva, Thaissa L.; Goulart, Marilia O.F.; de Simone, Carlos A.; Barbosa, Juliana M.C.; Salomao, Kelly; de Castro, Solange L.; Bower, John F.; da Silva Junior, Eufranio N.; European Journal of Medicinal Chemistry; vol. 136; (2017); p. 406 – 419;,
Ether – Wikipedia,
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