Adding a certain compound to certain chemical reactions, such as: 7664-66-6, name is 4-Isopropoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7664-66-6, Recommanded Product: 7664-66-6
The 234 mg (1mmol) 4 – iodo anisole, 465 mg (5mmol) aniline, 38 mg (0.2mmol) CuI, 116.4 mg (0.4mmol) ligand L14, 20mg (0.5mmol) NaOH, 2mL1, 5 – pentanediol, adding 10 ml reaction tube, sealing, 80 C reaction under the condition of 50h. After the stop of the reaction, water, extracted with ethyl acetate, washing, saturated salt water washing, after drying with anhydrous sodium sulfate, filtered, the filtrate is distilled under reduced pressure, purification by silica gel chromatography separation column column, N – 2, 4 – dimethyl shall phenylaniline 244 mg, yield 95%.
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Reference:
Patent; Sun Yat-sen University; Wan Yiqian; Ding Xiaomei; Huang Manna; Zhu Xinhai; Yi Zhou; CN106883132; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem