These common heterocyclic compound, 2688-84-8, name is 2-Phenoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2-Phenoxyaniline
A 100mL round bottom flask was charged with 1H-pyrrole-2-carboxaldehyde (1.862g, 20mmol), 2-Phenoxybenzenamine (3.704g, 20mmol) and 30mL methanol. After adding formic acid (0.01equiv, 0.2mmol), the mixture was stirred for 24h. The solution was evaporated to dryness, and recrystallized from CH2Cl2/n-hexane. Pure L1 was obtained as white powder. Yield: 4.82g, 92%. 1H NMR spectrum (400MHz, CDCl3, ppm), delta: 6.25(dd,1H), 6.62(dd,1H), 6.69(s,1H), 6.94(s,1H), 6.96(s,1H), 7.02(t,2H), 7.15(m,3H), 7.28(m,2H), 8.25 (s,1H), 9.32(s,1H). 13C NMR spectrum (100MHz, CDCl3,ppm), delta: 110.31, 116.50, 117.77, 120.9, 121.08, 122.45, 123.13, 124.75, 126.18, 129.52, 130.39, 143.95, 149.08, 150.72, 158.18. HRMS (m/z): [M+ H]+ calcd for 263.11789, found 263.11777.
The synthetic route of 2-Phenoxyaniline has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhang, Dan; Pang, Wenmin; Chen, Changle; Journal of Organometallic Chemistry; vol. 836-837; (2017); p. 56 – 61;,
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