Related Products of 31576-51-9,Some common heterocyclic compound, 31576-51-9, name is 2-(2-Methoxyethoxy)ethanamine, molecular formula is C5H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 2-(2-methoxyethoxy)ethan-1-amine (1.04 g, 8.72mmol, 1.10 eq) was added N,N-di-CBZ-1H-pyrazole-1-carbamidine (3.00 g, 7.93 mmol, 1.00eq) at 15 C. The mixture was stirred at 15C for 16 hrs. The reaction mixture wasconcentrated in vacuo. The residue was purified by silica gel column to give Compound 61(2.2 g) as colorless oil.?H NMR 400 MHz CDC13: oe 11.74 (s, 1H), 8.65 (s, 1H), 7.42-7.28 (m, 1OH), 5.20 (s, 2H), 5.14 (s, 2H), 3.68-3.64 (m, 6H), 3.59-3.58 (m, 2H), 3.41 (s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(2-Methoxyethoxy)ethanamine, its application will become more common.
Reference:
Patent; AFFERENT PHARMACEUTICALS INC.; HAWLEY, Ronald Charles; IBRAHIM, Prabha; FORD, Anthony, P.; GEVER, Joel, R.; (171 pag.)WO2017/160569; (2017); A1;,
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