Piergentili, Alessandro;Gentili, Francesco;Ghelfi, Francesca;Marucci, Gabriella;Pigini, Maria;Quaglia, Wilma;Giannella, Mario published 《Muscarinic subtypes profile modulation within a series of new antagonists, bridged bicyclic derivatives of 2,2-Diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine》. The research results were published in《Bioorganic & Medicinal Chemistry》 in 2003.HPLC of Formula: 2235-01-0 The article conveys some information:
A set of new muscarinic antagonists, bridged bicyclic derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine, was synthesized and tested to evaluate their affinity and selectivity for M1, M2, M3 and M4 receptor subtypes. The conformational constraint of the lead compound in a bicyclic structure, and the variation in distance and stereochem. of the active functions allowed us to modulate the selectivity of interaction with the M1-M3 receptor subtypes. The most interesting compound was (cis,trans)-2-(2,2-diphenylethyl)-5-methyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole oxalate (I oxalate), which is equipotent with Pirenzepine on rabbit vas deferens (M1-putative) but shows a better selectivity profile.Dimethoxydiphenylmethane (cas: 2235-01-0) were involved in the experimental procedure.
Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. HPLC of Formula: 2235-01-0 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem