Sparey, Tim; Beher, Dirk; Best, Jonathan; Biba, Mirlinda; Castro, Jose L.; Clarke, Earl; Hannam, Joanne; Harrison, Timothy; Lewis, Huw; Madin, Andrew; Shearman, Mark; Sohal, Bindi; Tsou, Nancy; Welch, Christopher; Wrigley, Jonathan published the artcile< Cyclic sulfamide γ-secretase inhibitors>, Product Details of C3H8ClNO2S, the main research area is cyclic sulfamide derivative preparation gamma secretase inhibitor.
A novel series of N-alkyl-substituted cyclic sulfamides were developed from a screening hit. Chemistries were developed which allowed surveys of N-alkyl groups and amines resulting in the identification of N-trifluoroethyl-substituted cyclic sulfamides with good in vitro and in vivo γ-secretase activity. One compound with subnanomolar activity elicited a reduction in brain Aβ40 after oral dosing in APP-YAC mice.
Bioorganic & Medicinal Chemistry Letters published new progress about Alzheimer disease. 10305-42-7 belongs to class ethers-buliding-blocks, and the molecular formula is C3H8ClNO2S, Product Details of C3H8ClNO2S.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem