《Suzuki-Miyaura Cross-Coupling of Sulfoxides》 was published in ACS Catalysis in 2020. These research results belong to Chen, Qianwei; Wu, Shufeng; Yan, Shuqin; Li, Chengxi; Abduhulam, Hayrul; Shi, Yanhui; Dang, Yanfeng; Cao, Changsheng. Application of 10365-98-7 The article mentions the following:
The utilization of di-Ph sulfoxides as versatile electrophilic coupling partners for the Suzuki-Miyaura reaction via C-S bond cleavage was successfully developed under palladium-N-heterocyclic carbene catalysis. The reactions showed good functional group compatibility, proceeded well under mild conditions, and provided biaryls in yields of up to 96%. A wide range of useful functional groups, such as fluoro, chloro, ether, hydroxyl, amide, cyano, keto, TMS and ester were tolerated under the reaction conditions, however the use of phenylboronic anhydride and arylboronic acid pinacol esters generally would lead low yields. Good regioselectivity for the electron-poor Ph group was achieved when unsym. di-Ph sulfoxides were used. The protocol is applicable at the gram scale even with half the amount of catalyst. D. functional theory calculations were performed to investigate the reaction mechanism, indicating that the reaction occurred through oxidative addition, transmetalation, and reductive elimination to provide the final coupling product. The results came from multiple reactions, including the reaction of 3-Methoxyphenylboronic acid(cas: 10365-98-7Application of 10365-98-7)
3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Application of 10365-98-7
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