In 2019,Tetrahedron included an article by Gergely, Mate; Kollar, Laszlo. Category: ethers-buliding-blocks. The article was titled 《Synthesis of benzamide-benzothiazole conjugates via palladium-catalyzed aminocarbonylation (hydrazinocarbonylation)》. The information in the text is summarized as follows:
The palladium-catalyzed aminocarbonylation of iodoarenes was investigated using 2-amino- and 2-hydrazinobenzothiazole as N-nucleophile. The reaction proved to be highly chemoselective in all cases: carboxamides and the corresponding carbohydrazides obtained by the acylation at the nitrogen adjacent to the C-2 of the benzothiazole moiety, were obtained exclusively and isolated in moderate to high yields. Systematic investigation of the reaction conditions revealed that the reaction requires relatively high temperature (higher than 70°). The effect of the carbon monoxide pressure is different in the synthesis of the two types of products: while the carboxamide formation is favored, the carbohydrazide formation is lowered by the increasing CO pressure. In the experimental materials used by the author, we found 1-Iodo-2-methoxybenzene(cas: 529-28-2Category: ethers-buliding-blocks)
1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem