Kato, Shota; Mizukami, Daichi; Sugai, Tomoya; Tsuda, Masashi; Fuwa, Haruhiko published their research in Chemical Science in 2021. The article was titled 《Total synthesis and complete configurational assignment of amphirionin-2》.Reference of 2-(Benzyloxy)acetaldehyde The article contains the following contents:
Herein the first total synthesis of amphirionin-2 and determination of its absolute configuration was disclosed. This synthesis featured an extensive use of cobalt-catalyzed Mukaiyama-type cyclization of γ-hydroxy olefins for stereoselective formation of all the THF rings found in the natural product and a late-stage Stille-type coupling for convergent assembly of the entire carbon backbone. Four candidate diastereomers of amphirionin-2 were synthesized in a unified, convergent manner and their spectroscopic/chromatog. properties were compared with those of the authentic material. The present study culminated in the reassignment of the C5/C7 relative configuration, assignment of the C12/C18 relative configuration, and determination of the absolute configuration of amphirionin-2. In the experimental materials used by the author, we found 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Reference of 2-(Benzyloxy)acetaldehyde)
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Reference of 2-(Benzyloxy)acetaldehyde
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem