《Multiple reactivities of flavonoids towards pathological elements in Alzheimer’s disease: structure-activity relationship》 was published in Chemical Science in 2020. These research results belong to Nam, Geewoo; Hong, Mannkyu; Lee, Juri; Lee, Hyuck Jin; Ji, Yonghwan; Kang, Juhye; Baik, Mu-Hyun; Lim, Mi Hee. Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal The article mentions the following:
Amyloid-β (Aβ) accumulation, metal ion dyshomeostasis, oxidative stress, and cholinergic deficit are four major characteristics of Alzheimer’s disease (AD). Herein, we report the reactivities of 12 flavonoids against four pathogenic elements of AD: metal-free and metal-bound Aβ, free radicals, and acetylcholinesterase. A series of 12 flavonoids was selected based on the mol. structures that are responsible for multiple reactivities including hydroxyl substitution and transfer of the B ring from C2 to C3. Our exptl. and computational studies reveal that the catechol moiety, the hydroxyl groups at C3 and C7, and the position of the B ring are important for instilling multiple functions in flavonoids. We establish a structure-activity relationship of flavonoids that should be useful for designing chem. reagents with multiple reactivities against the pathol. factors of AD. In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal) was used in this study.
N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal
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