In 2022,Rosendale, Morgane; Daniel, Jonathan; Castet, Frederic; Pagano, Paolo; Verlhac, Jean-Baptiste; Blanchard-Desce, Mireille published an article in Molecules. The title of the article was 《Stealth Luminescent Organic Nanoparticles Made from Quadrupolar Dyes for Two-Photon Bioimaging: Effect of End-Groups and Core》.Quality Control of Bis(4-methoxyphenyl)amine The author mentioned the following in the article:
Mol.-based Fluorescent Organic Nanoparticles (FONs) are versatile light-emitting nano-tools whose properties can be rationally addressed by bottom-up mol. engineering. A challenging property to gain control over is the interaction of the FONs′ surface with biol. systems. Indeed, most types of nanoparticles tend to interact with biol. membranes. To address this limitation, we recently reported on two-photon (2P) absorbing, red to near IR (NIR) emitting quadrupolar extended dyes built from a benzothiadiazole core and diphenylamino endgroups that yield spontaneously stealth FONs. In this paper, we expand our understanding of the structure-property relationship between the dye structure and the FONs 2P absorption response, fluorescence and stealthiness by characterizing a dye-related series of FONs. We observe that increasing the strength of the donor end-groups or of the core acceptor in the quadrupolar (D-π-A-π-D) dye structure allows for the tuning of optical properties, notably red-shifting both the emission (from red to NIR) and 2P absorption spectra while inducing a decrease in their fluorescence quantum yield. Thanks to their strong 1P and 2P absorption, all FONs whose median size varies between 11 and 28 nm exhibit giant 1P (106 M-1.cm-1) and 2P (104 GM) brightness values. Interestingly, all FONs were found to be non-toxic, exhibit stealth behavior, and show vanishing non-specific interactions with cell membranes. We postulate that the strong hydrophobic character and the rigidity of the FONs building blocks are crucial to controlling the stealth nano-bio interface. After reading the article, we found that the author used Bis(4-methoxyphenyl)amine(cas: 101-70-2Quality Control of Bis(4-methoxyphenyl)amine)
Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Quality Control of Bis(4-methoxyphenyl)amine
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem