On July 4, 2013, Chen, Wei; Loury, David J. published a patent.Computed Properties of 1417036-28-2 The title of the patent was Preparation of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine derivatives as Btk kinase inhibitors. And the patent contained the following:
The invention related to pyrazolo[3,4-d]pyrimidine derivatives of formula I and their pharmaceutically acceptable salts as Bruton’s tyrosine kinase (Btk) inhibitors; pharmaceutical composition comprising them and their preparations and use thereof. Compounds of formula I wherein A is CH and N; Y is (un)substituted (hetero)arylene, cycloalkylene, heteroalkylene, etc; Z is CO, NHCO, NHSO1-2, etc.; R6, R7 and R8 are independently H and L-J-W; L and J are independently a bond, (un)substituted C1-6 alkylene, (un)substituted C3-6 cycloalkylene, etc.; W is H, NH2 and derivatives; R2 is H, CN, NO2, etc.; R4 is independently H, CN, NO2, etc.; and their pharmaceutically acceptable salt, are claimed. Example compound II was prepared by amination of (R)-tert-Bu 3-hydroxy-1-pyrrolidinecarboxylate with 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine,the resulting substituted pyrazolopyrimidine underwent deprotection followed by N-acylation with 4-(dimethylamino)but-2-enoic acid to afford 2-(E)-1-[(R)-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidin-1-yl]-4-(dimethylamino)but-2-en-1-one, which underwent coupling reaction with 4-chlorophenylboronic acid to afford compound II. The invention compounds were evaluated for their Btk inhibitory activity. From the assay, it was determined that example compound II exhibited IC50 value of < 100 nM. The experimental process involved the reaction of 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1417036-28-2).Computed Properties of 1417036-28-2
The Article related to pyrazolopyrimidine preparation btk kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Computed Properties of 1417036-28-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem