On November 19, 1992, Achard, Daniel; Grisoni, Serge; Hanessian, Stephen; Moutonnier, Claude; Peyronel, Jean Francois; Tabart, Michel; Truchon, Alain published a patent.Electric Literature of 81616-80-0 The title of the patent was Preparation of N-acyltetrahydroisoindoles as drugs. And the patent contained the following:
Title compounds [I; R1 = H; R1R1 = bond; R2 = Ph, halophenyl, tolyl; R3 = halo, OH; R4 = H, halo; R5 = C(:X)CHRR’; R = Ph, alkyl, alkoxy, heterocyclyl, etc.; R’ = H, halo, OH, alkyl, etc.; X = O, NH] were prepared as substance P antagonists (no data). Thus, 4,4-diphenyl-2-cyclohexenone was cyclocondensed with PhCH2N(CH2OBu)CH2SiMe3 and the product converted in 7 steps to fluorotetrahydroisoindole (R,R,R)-II (III; R5 = H) which was N-acylated by 2-[Me2N(CH2)3O]C6H4CH2CO2H (preparation given) to give III.HCl [R5 = COCH2C6H4[O(CH2)3NMe2]-2]. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Electric Literature of 81616-80-0
The Article related to isoindole acyltetrahydro substance p antagonist, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Electric Literature of 81616-80-0
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem