On September 3, 2015, Sherer, Brian; Brugger, Nadia published a patent.Reference of 3-(2-Methoxyphenoxy)benzaldehyde The title of the patent was Preparation of heterocyclic compounds as NaV channel inhibitors. And the patent contained the following:
The title compounds I [Z1 = CR2, C(O), C(S), C(NR); Z2 = CR2, O, S, SO, SO2, NR; X = O, S, SO2, SO, C(O), CO2, C(O)NR, NRC(O), NRC(O)NR, NRSO2, NR; or X is absent; A = (un)substituted alkyl, C5-10 aryl, 3-8 membered saturated or partially unsaturated carbocyclic ring, 3-7 membered heterocylic ring, or a 5-6 membered heteroaryl ring; R1 = R, halo, haloalkyl, etc.; R2-R5 = (independently) = H or alkyl; Y = CH2, O, S, SO2, SO, C(O), CO2, C(O)NR, NRC(O), NRC(O)NR, NRSO2, NR; B = (un)substituted C5-10 aryl or 5-6 membered heteroaryl ring; R6 = R, halo, haloalkyl, etc.; R = H, (un)substituted alkyl, C5-10 aryl, 3-8 membered saturated or partially unsaturated carbocyclic ring, 3-7 membered heterocylic ring having 1-4 heteroatoms selected from N, O, or S, or 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms selected from N, O, or S; or two R groups on the same atom are taken together with the atom to which they are attached to form C3-10 aryl, 3-8 membered saturated or partially unsaturated carbocyclic ring, 3-7 membered heterocylic ring having 1-4 heteroatoms selected from N, O, or S, or 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms selected from N, O, or S; m = 0-3; n = 0-3; q = 0-3; r = 1-2], useful as NaV1.6 inhibitors, were prepared and formulated. E.g., a multi-step synthesis of II, starting from pyrrolidine-1,3-dicarboxylic acid 1-tert-Bu ester and pyridin-2-yl-methylamine, was described. Exemplified compounds I were evaluated for their activity as NaV1.6 inhibitors (data given). The experimental process involved the reaction of 3-(2-Methoxyphenoxy)benzaldehyde(cas: 66855-92-3).Reference of 3-(2-Methoxyphenoxy)benzaldehyde
The Article related to heterocyclic compound pyrrolidinecarboxamide preparation sodium channel nav inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyrroles and Pyrrolizines and other aspects.Reference of 3-(2-Methoxyphenoxy)benzaldehyde
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