β(4-Hydroxy-2-methylphenoxy)lactic acid, a metabolite of mephenesin was written by Ludwig, B. J.;Luts, H.;West, W. A.. And the article was included in Journal of the American Chemical Society in 1955.Recommanded Product: 4-(Benzyloxy)-3-methylphenol The following contents are mentioned in the article:
2,1,4-MeC6H3(OH)2 (I) (24.8 g.) in 8.0 g. NaOH in 100 cc. H2O, the mixture refluxed 2 hrs. with 12.5 g. ClCH2CH(OH)CO2H (II), cooled, saturated with CO2, and washed with Et2O to recover 19.5 g. unchanged I, the aqueous layer concentrated in vacuo, acidified with HCl, and extracted with Et2O, the extract evaporated, the residue (2.6 g.) sublimed in vacuo to remove unchanged I, and the tan-colored, solid residue (1.5 g.) recrystallized repeatedly from hot PrNO2 gave 3,4-Me(HO)C6H3OCH2CH(OH)CO2H, slightly colored crystals, m. 121-2°. Dihydropyran (16.8 g.) added with stirring to 12.4 g. I in 100 cc. dioxane containing 2 drops concentrated HCl at 25-30°, the mixture allowed to warm to 60°, and diluted with Et2O, the organic layer extracted with 10% aqueous NaOH, the alk. solution neutralized with CO2, diluted with H2O, and extracted with CCl4, the extract evaporated, and the colored residue (5.3 g.) recrystallized from Et2O-ligroine containing a drop dihydropyran gave 4- hydroxy-3-methylphenyl-2-tetrahydropyranyl ether (III), white crystals, m. 90-1.5°. III (4.16 g.) in 12 g. 10% aqueous NaOH refluxed 3 hrs. with 1.25 g. II, the solution cooled, saturated with CO2, and extracted with Et2O, the aqueous portion acidified with HCl, saturated with Na2SO4, and extracted with Et2O, the extract dried and evaporated, and the colored, solid residue (0.8 g.) recrystallized twice from C6H6-Et2O and once from PrNO2 gave 410 mg. 2,4-Me(HO)C6H3OCH2CH(OH)CO2H (IV), m. 168-9°. Synthetic and natural IV were identical with regard to their m.p., ultraviolet absorption, color test with Ehrlich reagent, and chromatographic behavior on paper. III (1.04 g.) treated in the usual manner with 1 equivalent PhCH2Cl in 1 equivalent aqueous NaOH, the intermediate mixed diether hydrolyzed, and the mixture worked up in the usual manner gave a small amount of 2,5-PhCH2(HO)C6H3Me, white crystals, m. 69.5-70.5°. This study involved multiple reactions and reactants, such as 4-(Benzyloxy)-3-methylphenol (cas: 100927-02-4Recommanded Product: 4-(Benzyloxy)-3-methylphenol).
4-(Benzyloxy)-3-methylphenol (cas: 100927-02-4) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 4-(Benzyloxy)-3-methylphenol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem