A synthesis-driven structure revision of plagiochin E, a highly bioactive bisbibenzyl was written by Speicher, Andreas;Groh, Matthias;Zapp, Josef;Schaumloeffel, Anu;Knauer, Michael;Bringmann, Gerhard. And the article was included in Synlett in 2009.Category: ethers-buliding-blocks The following contents are mentioned in the article:
Recently, a bis-bibenzyl named plagiochin E showing remarkable antifungal and antitumor activities was isolated from Marchantia polymorpha, a liverwort. The total synthesis of the proposed structure for plagiochin E and of 2 structurally and biosynthetically related bis-bibenzyls and comparison of the NMR of the synthetic compounds with those of the isolated bis-bibenzyls necessitates a structure revision for plagiochin E. The isolated bis-bibenzyl called plagiochin E proved to be riccardin D. Exemplarily for this metabolite, the stereostructure was investigated, by racemate resolution on a chiral Lux Cellulose-1 phase with HPLC-CD coupling and quantum chem. CD calculations, clearly assigning the P-configuration for the faster and the M-configuration to the slower enantiomer. This study involved multiple reactions and reactants, such as 5-Methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (cas: 1132669-90-9Category: ethers-buliding-blocks).
5-Methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (cas: 1132669-90-9) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem