Rohde, Jason M. et al. published their research in Journal of Medicinal Chemistry in 2021 | CAS: 109-85-3

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 109-85-3

Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer was written by Rohde, Jason M.;Karavadhi, Surendra;Pragani, Rajan;Liu, Li;Fang, Yuhong;Zhang, Weihe;McIver, Andrew;Zheng, Hongchao;Liu, Qingyang;Davis, Mindy I.;Urban, Daniel J.;Lee, Tobie D.;Cheff, Dorian M.;Hollingshead, Melinda;Henderson, Mark J.;Martinez, Natalia J.;Brimacombe, Kyle R.;Yasgar, Adam;Zhao, Wei;Klumpp-Thomas, Carleen;Michael, Sam;Covey, Joseph;Moore, William J.;Stott, Gordon M.;Li, Zhuyin;Simeonov, Anton;Jadhav, Ajit;Frye, Stephen;Hall, Matthew D.;Shen, Min;Wang, Xiaodong;Patnaik, Samarjit;Boxer, Matthew B.. And the article was included in Journal of Medicinal Chemistry in 2021.Reference of 109-85-3 The following contents are mentioned in the article:

Neomorphic mutations in isocitrate dehydrogenase 1 (IDH1) are oncogenic for a number of malignancies, primarily low-grade gliomas and acute myeloid leukemia. We report a medicinal chem. campaign around a 7,7-dimethyl-7,8-dihydro-2H-1λ2-quinoline-2,5(6H)-dione screening hit against the R132H and R132C mutant forms of isocitrate dehydrogenase (IDH1). Systematic SAR efforts produced a series of potent pyrid-2-one mIDH1 inhibitors, including the atropisomer (+)-119 (NCATS-SM5637, NSC 791985). In an engineered mIDH1-U87-xenograft mouse model, after a single oral dose of 30 mg/kg, 16 h post dose, between 16 and 48 h, (+)-119(I) showed higher tumoral concentrations that corresponded to lower 2-HG concentrations, when compared with the approved drug AG-120 (ivosidenib). This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Reference of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem