Synthesis of N-azaaryl anilines: an efficient protocol via smiles rearrangement was written by Xia, Shuai;Wang, Li-Ying;Sun, Heng-Zhi;Yue, Huan;Wang, Xiu-Hua;Tan, Jia-Lian;Wang, Yin;Hou, Di;He, Xiao-Yan;Mun, Ki-Cheol;Kumar, B. Prem;Zuo, Hua;Shin, Dong-Soo. And the article was included in Bulletin of the Korean Chemical Society in 2013.Safety of N-(4-Methoxyphenyl)pyridin-3-amine The following contents are mentioned in the article:
An efficient process for the synthesis of N-azaaryl anilines involves a Smiles rearrangement as a tool. A variety of N-azaaryl anilines were generated by a reaction of substituted phenols, substituted anilines, aminopyridine derivatives, chloroacetyl chloride or pyridinol derivatives, under basic reaction conditions in good to excellent yields. The synthesis of the target compounds was achieved by a reaction of 3-pyridinamine with chloroacetyl chloride, formation of an amide and reaction with phenol, thus providing 2-(phenoxy)-N-(3-pyridinyl)acetamide (I) and similar intermediates, which underwent a Smiles rearrangement. The title compounds thus formed included N-phenyl-3-pyridinamine (II) and related substances, such as N-phenyl-2-pyridinamine derivatives This study involved multiple reactions and reactants, such as N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2Safety of N-(4-Methoxyphenyl)pyridin-3-amine).
N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Safety of N-(4-Methoxyphenyl)pyridin-3-amine
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem