Metal-Free Intermolecular Azide-Alkyne Cycloaddition Promoted by Glycerol was written by Rodriguez-Rodriguez, Marta;Gras, Emmanuel;Pericas, Miquel A.;Gomez, Montserrat. And the article was included in Chemistry – A European Journal in 2015.COA of Formula: C6H10O2 This article mentions the following:
Metal-free intermol. Huisgen cycloadditions using nonactivated internal alkynes were successfully performed in neat glycerol, both under thermal and microwave dielec. heating. In sharp contrast, no reaction occurs in other protic solvents, such as H2O, EtOH, or diols. DFT calculations showed that the BnN3/glycerol adduct promotes a more important stabilization of the corresponding LUMO than that produced in the analogous BnN3/alc. adducts, favoring the reactivity with the alkyne in the 1st case. The presence of Cu salts in the medium did not change the reaction pathway (Cu(I) acts as spectator), except for disubstituted silylalkynes, for which desilylation takes place in contrast to the metal-free system. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8COA of Formula: C6H10O2).
1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.COA of Formula: C6H10O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem