Practical Electrochemical Iodination of Aromatic Compounds was written by Kataoka, Kazuhide;Hagiwara, Yuji;Midorikawa, Koji;Suga, Seiji;Yoshida, Jun-ichi. And the article was included in Organic Process Research & Development in 2008.Category: ethers-buliding-blocks This article mentions the following:
A practical method for electrochem. iodination of aromatic compounds was developed. The method involves the generation of I+ by electrochem. oxidation of I2 in MeCN using H2SO4 as supporting electrolyte followed by the reaction with aromatic compounds The para/ortho selectivity for the reaction of monosubstituted benzenes was significantly improved using dimethoxyethane as cosolvent in the 2nd step. The reaction with highly reactive aromatic compounds gave significant amounts of diiodo compounds in a macrobatch reactor. This problem was solved by fast 1:1 mixing of I+ with an aromatic compound using a microflow system consisting of a T-shaped micromixer and a microtube reactor. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2Category: ethers-buliding-blocks).
4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem