Room Temperature C-H Activation and Cross-Coupling of Aryl Ureas in Water was written by Nishikata, Takashi;Abela, Alexander R.;Lipshutz, Bruce H.. And the article was included in Angewandte Chemie, International Edition in 2010.Safety of N-(3-Methoxyphenyl)pivalamide This article mentions the following:
The first room temperature mono-C-H activation of urea derivatives and their cross-coupling with aryl iodides in water is described. This methodol. provides a convenient route to various aniline derivatives by means of C-H activation under mild conditions. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Safety of N-(3-Methoxyphenyl)pivalamide).
N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Safety of N-(3-Methoxyphenyl)pivalamide
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem