Evaluation of acrylophenones and related bis-Mannich bases against murine P388 leukemia was written by Dimmock, Jonathan R.;Patil, Shirish A.;Leek, Donald M.;Warrington, Robert C.;Fang, Wei D.. And the article was included in European Journal of Medicinal Chemistry in 1987.HPLC of Formula: 54916-28-8 This article mentions the following:
Mannich reaction of acetophenones with bases gave acrylophenones and bis-Mannich bases I and II (R = H, Me, Cl, OMe; R1 = H, Cl; R2 = H, OMe, Me, OPh, OC6H4OMe-4, OC6H4Me-4, OC6H4Cl-4; R3 = H, OMe, Me). I and II were tested against P388 lymphocyte leukemia in mice. I (R = R1 = R3 = H, R2 = OMe) shows potent activity against P388 cells in vitro. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8HPLC of Formula: 54916-28-8).
1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).HPLC of Formula: 54916-28-8
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem