Palladium catalyzed migratory heck coupling of arteannuin B and boronic acids: An approach towards the synthesis of antiproliferative agents in breast and lung cancer cells was written by Rasool, Javeed Ur;Mir, Khalid Bashir;Shaikh, Majeed;Bhat, Aabid H.;Nalli, Yedukondalu;Khalid, Anam;Ahmad, Syed Mudabir;Goswami, Anindya;Ali, Asif. And the article was included in Bioorganic Chemistry in 2022.Formula: C14H15BO4 This article mentions the following:
We have recently highlighting the role of spiroisoxazoline arteannuin B derivatives in mediating proinflammatory cytokines like IL-6, TNf浼?and NO in vitro. In the present study, a series of new 灏?arylated arteannuin B analogs were synthesized through coupling with arylboroic acids and evaluated for their in vitro cytotoxic activity in a panel of six cancer cell lines. The binding efficiency was verified by docking of the original ligand within the active site of ATPase domain of GRP78 (PDB ID: 3LDL) at a resolution of 2.30 鑴?with the score energy of -8.07 kcal/mol. Among the new compounds 4-trifloromethane 灏?Ph arteannuin B, 4-Chloro 灏?Ph arteannuin B, 4-Et 灏?Ph arteannuin B, 4-Fluoro 灏?Ph arteannuin B, 3-Bromo-5-fluoro 灏?Ph arteannuin B and 4-OBn p-methoxy 灏?Ph arteannuin B displayed potent cytotoxic potential with an IC50 from 2 to 18娓璏 and compound 4-Fluoro 灏?Ph arteannuin B was proven to be the most potent cytotoxic and anti-proliferative compound of all the six distinct cell lines. Compound 4-Fluoro 灏?Ph arteannuin B exhibited promising apoptosis inducing potential in breast cancer cells and stalled their wound healing properties and was effective in blocking the migration of cancer cells. In the experiment, the researchers used many compounds, for example, (4-((4-Methoxybenzyl)oxy)phenyl)boronic acid (cas: 156635-90-4Formula: C14H15BO4).
(4-((4-Methoxybenzyl)oxy)phenyl)boronic acid (cas: 156635-90-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Formula: C14H15BO4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem