Schuetz, Christian et al. published their research in European Journal of Medicinal Chemistry in 2021 | CAS: 75581-11-2

4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Reference of 75581-11-2

Divergent synthesis and biological evaluation of 2-(trifluoromethyl)pyridines as virulence-attenuating inverse agonists targeting PqsR was written by Schuetz, Christian;Hodzic, Amir;Hamed, Mostafa;Abdelsamie, Ahmed S.;Kany, Andreas M.;Bauer, Maximilian;Roehrig, Teresa;Schmelz, Stefan;Scrima, Andrea;Blankenfeldt, Wulf;Empting, Martin. And the article was included in European Journal of Medicinal Chemistry in 2021.Reference of 75581-11-2 This article mentions the following:

A short and divergent route towards new derivatives of 2-(trifluoromethyl)pyridines as potent inverse agonists of the bacterial target PqsR against Pseudomonas aeruginosa (PA) infections was described. This Gram-neg. pathogen causes severe nosocomial infections and common antibiotic treatment options were rendered ineffective due to resistance issues. Based on an earlier identified optimized hit, the derivatization and rigidification attempts employing two central building blocks were conducted. The western part of the mol. was built up via a 2-(trifluoromethyl)pyridine head group equipped with a terminal alkyne. The eastern section was then introduced through aryliode motifs exploiting Sonogashira as well as Suzuki-type chem. Subsequent modification provided quick access to an array of compounds, allowed for deep SAR insights, and enabled to optimize the hit scaffold into a lead structure of nanomolar potency combined with favorable in vitro ADME/T features. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2Reference of 75581-11-2).

4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Reference of 75581-11-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem