Zhang, Lei et al. published their research in Journal of Medicinal Chemistry in 2017 | CAS: 104197-14-0

4-Bromo-2,6-difluoroanisole (cas: 104197-14-0) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Category: ethers-buliding-blocks

The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging was written by Zhang, Lei;Chen, Laigao;Beck, Elizabeth M.;Chappie, Thomas A.;Coelho, Richard V.;Doran, Shawn D.;Fan, Kuo-Hsien;Humphrey, John M.;Hughes, Zoe;Kuszpit, Kyle;Lachapelle, Erik A.;Lazzaro, John T.;Mather, Robert J.;Patel, Nandini C.;Skaddan, Marc B.;Sciabola, Simone;Verhoest, Patrick R.;Young, Joseph M.;Zasadny, Kenneth;Villalobos, Anabella. And the article was included in Journal of Medicinal Chemistry in 2017.Category: ethers-buliding-blocks This article mentions the following:

As part of our effort in identifying phosphodiesterase (PDE) 4B-preferring inhibitors for the treatment of central nervous system (CNS) disorders, we sought to identify a positron emission tomog. (PET) ligand to enable target occupancy measurement in vivo. Through a systematic and cost-effective PET discovery process, involving expression level (Bmax) and biodistribution determination, a PET-specific structure-activity relationship (SAR) effort, and specific binding assessment using a LC-MS/MS “cold tracer” method, we have identified 8 (PF-06445974) as a promising PET lead. Compound 8 has exquisite potency at PDE4B, good selectivity over PDE4D, excellent brain permeability, and a high level of specific binding in the “cold tracer” study. In subsequent non-human primate (NHP) PET imaging studies, [18F]8 showed rapid brain uptake and high target specificity, indicating that [18F]8 is a promising PDE4B-preferring radioligand for clin. PET imaging. In the experiment, the researchers used many compounds, for example, 4-Bromo-2,6-difluoroanisole (cas: 104197-14-0Category: ethers-buliding-blocks).

4-Bromo-2,6-difluoroanisole (cas: 104197-14-0) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem