On May 4, 2006, Ghosh, Shomir; Elder, Amy; Guo, Jianping; Mani, Ukti; Patane, Michael; Carson, Kenneth; Ye, Qing; Bennett, Robert; Chi, Shannon; Jenkins, Tracy; Guan, Bing; Kolbeck, Roland; Smith, Sean; Zhang, Cheng; LaRosa, Gregory; Jaffee, Bruce; Yang, Hua; Eddy, Priya; Lu, Chuang; Uttamsingh, Vinita; Horlick, Robert; Harriman, Geraldine; Flynn, Daniel published an article.Reference of 3-(2-Methoxyphenoxy)benzaldehyde The title of the article was Design, Synthesis, and Progress toward Optimization of Potent Small Molecule Antagonists of CC Chemokine Receptor 8 (CCR8). And the article contained the following:
Activation of CCR8 by its ligand CCL1 may play an important role in diseases such as asthma, multiple sclerosis, and cancer. The study of small mol. CCR8 antagonists will help establish the validation of these hypotheses. We report the design, synthesis, and progress toward optimization of potent small mol. CCR8 antagonists identified from a high-throughput screen. These analogs exhibit good potency in binding and chemotaxis assays, show good selectivity vs. the hERG channel, and have good eADME (early absorption, distribution, metabolism, and excretion) profiles. The experimental process involved the reaction of 3-(2-Methoxyphenoxy)benzaldehyde(cas: 66855-92-3).Reference of 3-(2-Methoxyphenoxy)benzaldehyde
The Article related to ccr8 antagonist preparation sar herg channel, Pharmacology: Structure-Activity and other aspects.Reference of 3-(2-Methoxyphenoxy)benzaldehyde
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