Electrochemical Hydroxylation of Electron-Rich Arenes in Continuous Flow was written by Kooli, Anni;Wesenberg, Lars;Beslac, Marko;Krech, Anastasiya;Lopp, Margus;Noel, Timothy;Oseka, Maksim. And the article was included in European Journal of Organic Chemistry in 2022.Name: 4-Benzyloxyphenol The following contents are mentioned in the article:
A novel method for the synthesis of hydroxylated products ROH (R = 4-methoxyphenyl, 2-methoxy-5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl, phenanthren-9-yl, etc.) from electron-rich arenes such as anisole, phenanthrene, mesitylene, etc. that was achieved by the implementation of a continuous-flow setup was presented. The continuous nature of the process allowed to fine-tune the reactions conditions in order to prevent the decomposition of the sensitive products expanding the reaction scope beyond electron-poor and neutral arenes that were previously reported in the batch processes. Thus, synthetically valuable hydroxylated arenes were obtained in good yields with the residence time just over a minute. In order to demonstrate the reliability and the efficiency of the electrochem. flow setup, a scale up experiment was also performed. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Name: 4-Benzyloxyphenol).
4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: 4-Benzyloxyphenol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem