Electrochemical Hydroxylation of Electron-Rich Arenes in Continuous Flow was written by Kooli, Anni;Wesenberg, Lars;Beslac, Marko;Krech, Anastasiya;Lopp, Margus;Noel, Timothy;Oseka, Maksim. And the article was included in European Journal of Organic Chemistry in 2022.Synthetic Route of C13H12O2 The following contents are mentioned in the article:
A novel method for the synthesis of hydroxylated products ROH (R = 4-methoxyphenyl, 2-methoxy-5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl, phenanthren-9-yl, etc.) from electron-rich arenes such as anisole, phenanthrene, mesitylene, etc. that was achieved by the implementation of a continuous-flow setup was presented. The continuous nature of the process allowed to fine-tune the reactions conditions in order to prevent the decomposition of the sensitive products expanding the reaction scope beyond electron-poor and neutral arenes that were previously reported in the batch processes. Thus, synthetically valuable hydroxylated arenes were obtained in good yields with the residence time just over a minute. In order to demonstrate the reliability and the efficiency of the electrochem. flow setup, a scale up experiment was also performed. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Synthetic Route of C13H12O2).
4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C13H12O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem