A mild and practical method for deprotection of aryl methyl/benzyl/allyl ethers with HPPh2 and tBuOK was written by Pan, Wenjing;Li, Chenchen;Zhu, Haoyin;Li, Fangfang;Li, Tao;Zhao, Wanxiang. And the article was included in Organic & Biomolecular Chemistry in 2021.Category: ethers-buliding-blocks The following contents are mentioned in the article:
A general method for the demethylation, debenzylation, and deallylation of aryl ethers ROMe (R = C6H5, 3-FC6H4, 2-naphthyl, etc.), R1OCH2Ph (R1 = C6H5, 5,6,7,8-tetrahydronaphthalen-2-yl, 2-naphthyl, etc.) and R2OCH2CH=CH2 (R2 = C6H5, 2,3-dimethylphenyl, 1-naphthyl, etc.) using HPPh2 and tBuOK is reported. The reaction features mild and metal-free reaction conditions, broad substrate scope, good functional group compatibility, and high chem. selectivity towards aryl ethers over aliphatic structures. Notably, this approach is competent to selectively deprotect the allyl or benzyl group, making it a general and practical method in organic synthesis. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Category: ethers-buliding-blocks).
4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem